{"id":1389,"date":"2020-04-14T08:15:04","date_gmt":"2020-04-14T08:15:04","guid":{"rendered":"https:\/\/fondvlongo.wpengine.com\/demo\/?page_id=1389"},"modified":"2026-04-16T11:57:17","modified_gmt":"2026-04-16T09:57:17","slug":"diabetes-obesity-for-doctors","status":"publish","type":"page","link":"https:\/\/www.fondazionevalterlongo.org\/en\/diabetes-obesity-for-doctors\/","title":{"rendered":"DIABETES &#038; OBESITY"},"content":{"rendered":"<style>\n.pub-nav { display: flex; flex-wrap: wrap; gap: 8px; margin-bottom: 28px; }\n.pub-nav a { font-size: 11px; font-weight: 700; letter-spacing: 0.07em; color: #D36E13; border: 1px solid #D36E13; border-radius: 3px; padding: 4px 10px; text-decoration: none; transition: background 0.2s, color 0.2s; }\n.pub-nav a:hover { background: #D36E13; color: #fff; }\n.pubblicazioni-lista { margin-top: 8px; }\n.pubblicazione-item { padding: 14px 0; border-bottom: 0.5px solid #e8e8e8; }\n.pubblicazione-item:last-child { border-bottom: none; }\n.rivista-label { display: block; font-size: 11px; font-weight: 700; letter-spacing: 0.08em; text-transform: uppercase; color: #D36E13; margin-bottom: 6px; }\n.pub-link { font-size: 14px; line-height: 1.6; color: #1a5fa8; text-decoration: underline; text-decoration-color: rgba(26,95,168,0.35); text-underline-offset: 3px; display: inline; }\n.pub-link:hover { color: #D36E13; text-decoration-color: #D36E13; }\n.pub-link em { font-style: italic; }\n.arrow-icon { display: inline-block; font-size: 11px; margin-left: 5px; color: rgba(26,95,168,0.55); text-decoration: none; vertical-align: middle; }\n.intro-text { font-size: 15px; line-height: 1.7; color: #54565A; margin-bottom: 8px; }\n.section-note { font-size: 11px; color: #888; margin-top: 24px; padding-top: 16px; border-top: 0.5px solid #e8e8e8; }\n.year-divider { font-size: 11px; font-weight: 700; letter-spacing: 0.1em; text-transform: uppercase; color: #bbb; margin: 28px 0 4px 0; padding-bottom: 6px; border-bottom: 0.5px solid #e8e8e8; clear: both; display: block; }\n<\/style>\n<div class=\"content_info\">\n<h1>Scientific Publications: Diabetes and Obesity<\/h1>\n<p class=\"intro-text\">The following collection gathers the main scientific publications on the role of the fasting-mimicking diet, periodic fasting and dietary restriction in the treatment of type 2 diabetes, obesity and related metabolic conditions.<\/p>\n<nav class=\"pub-nav\">\n  <a href=\"#y2025\">2025<\/a><br \/>\n  <a href=\"#y2024\">2024<\/a><br \/>\n  <a href=\"#y2023\">2023<\/a><br \/>\n  <a href=\"#y2022\">2022<\/a><br \/>\n  <a href=\"#y2020\">2020<\/a><br \/>\n  <a href=\"#y2017\">2017<\/a><br \/>\n  <a href=\"#y2011\">2011<\/a><br \/>\n  <a href=\"#y2006\">2006<\/a><br \/>\n  <a href=\"#y2003\">2003<\/a><br \/>\n<\/nav>\n<div class=\"pubblicazioni-lista\">\n<div class=\"year-divider\" id=\"y2025\">2025<\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Molecular Metabolism \/ 2025<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/www.fondazionevalterlongo.org\/wp-content\/uploads\/2026\/04\/2025_Sulaj_Molecular-Metabolism.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Sulaj A. et al. \u2014 Effects of periodic fasting on glucose metabolism and diabetic nephropathy: long-term follow-up. <em>Mol Metab<\/em>, 2025.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Journal of Personalized Medicine \/ 2025<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/www.fondazionevalterlongo.org\/wp-content\/uploads\/2026\/04\/2025_Roshan_Journal-of-Personalized-Medicine.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Roshan S. et al. \u2014 Personalized approaches to the fasting-mimicking diet in the treatment of type 2 diabetes: clinical evidence. <em>J Pers Med<\/em>, 2025.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Metabolic Health and Disease \/ 2025<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/www.fondazionevalterlongo.org\/wp-content\/uploads\/2026\/04\/2025_Mishra_Metabolic-Health-and-Disease-2.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Mishra A. et al. \u2014 IGF-I deficiency and metabolic protection in diabetes: mechanisms and clinical implications. <em>Metab Health Dis<\/em>, 2025.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Cell Reports Medicine \/ 2025<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/www.fondazionevalterlongo.org\/wp-content\/uploads\/2026\/04\/2025_Micarelli_Cell-Reports-Medicine-2.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Micarelli A. et al. \u2014 Effects of the fasting-mimicking diet on biological age markers and metabolic risk. <em>Cell Rep Med<\/em>, 2025.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"year-divider\" id=\"y2024\">2024<\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Diabetologia \/ 2024<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/www.fondazionevalterlongo.org\/wp-content\/uploads\/2026\/04\/2024_van-den-Burg_Diabetologia.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">van den Burg E.L. et al. \u2014 Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial. <em>Diabetologia<\/em>, 2024.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Nature Communications \/ 2024<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38378685\/\" target=\"_blank\" rel=\"noopener noreferrer\">Brandhorst S. et al. \u2014 Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. <em>Nat Commun<\/em>, 15(1):1309, 2024.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Med \/ 2024<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/www.fondazionevalterlongo.org\/wp-content\/uploads\/2026\/04\/2024_Mishra_Med_Normal-or-improved-cardiovascular-risk-factors-in-IGF-I-deficient-adults-with-growth-hormone-receptor-deficiency-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Mishra A. et al. \u2014 Normal or improved metabolic risk factors in IGF-I-deficient adults with growth hormone receptor deficiency. <em>Med<\/em>, 2024.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Value in Health \/ 2024<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/www.fondazionevalterlongo.org\/wp-content\/uploads\/2026\/04\/2024_Habka_Value-in-health.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Habka D. et al. \u2014 Cost-effectiveness analysis of the fasting-mimicking diet in the treatment of type 2 diabetes in primary care. <em>Value Health<\/em>, 2024.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"year-divider\" id=\"y2023\">2023<\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Metabolic Health and Disease \/ 2023<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/www.fondazionevalterlongo.org\/wp-content\/uploads\/2026\/04\/2023_Mishra_Metabolic-Health-and-Disease-1.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Mishra A. et al. \u2014 IGF-I deficiency and reduced metabolic risk: evidence from populations with growth hormone receptor deficiency. <em>Metab Health Dis<\/em>, 2023.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"year-divider\" id=\"y2022\">2022<\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">The Journal of Clinical Endocrinology and Metabolism \/ 2022<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35661214\/\" target=\"_blank\" rel=\"noopener noreferrer\">Sulaj A. et al. \u2014 Six-month periodic fasting in patients with type 2 diabetes and diabetic nephropathy: a proof-of-concept study. <em>J Clin Endocrinol Metab<\/em>, 107(8):2167-2181, 2022.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"year-divider\" id=\"y2020\">2020<\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">BMC Endocrine Disorders \/ 2020<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33143722\/\" target=\"_blank\" rel=\"noopener noreferrer\">van den Burg E.L. et al. \u2014 Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes. <em>BMC Endocr Disord<\/em>, 20(1):164, 2020.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"year-divider\" id=\"y2017\">2017<\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Cell \/ 2017<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/www.dropbox.com\/sh\/wmq7q6azyzfsubm\/AAC3RUJdUkkmnz0XMBh8tbAma\/Diabetes%20and%20Obesity\/2017-02-23_Cell_Pancreas.pdf?dl=0\" target=\"_blank\" rel=\"noopener noreferrer\">Cheng C.W. et al. \u2014 Fasting-mimicking diet promotes Ngn3-driven \u03b2-cell regeneration to reverse diabetes. <em>Cell<\/em>, 2017.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Science Translational Medicine \/ 2017<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/www.fondazionevalterlongo.org\/wp-content\/uploads\/2026\/04\/2017_Wei_Science-translational-medicine-2.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Wei M. et al. \u2014 Fasting-mimicking diet and markers\/risk factors for aging, diabetes, cancer, and cardiovascular disease. <em>Sci Transl Med<\/em>, 9(377):eaai8700, 2017.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"year-divider\" id=\"y2011\">2011<\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Science Translational Medicine \/ 2011<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/www.dropbox.com\/sh\/wmq7q6azyzfsubm\/AAB9m-3FuvTlLX1FTik-iJAHa\/Diabetes%20and%20Obesity\/2011_Sci%20Transl%20Med.pdf?dl=0\" target=\"_blank\" rel=\"noopener noreferrer\">Guevara-Aguirre J. et al. \u2014 Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. <em>Sci Transl Med<\/em>, 2011.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"year-divider\" id=\"y2006\">2006<\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Biochimica et Biophysica Acta \/ 2006<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/www.fondazionevalterlongo.org\/wp-content\/uploads\/2026\/04\/2006-Longo-Sirtuins-in-aging-and-age-related-d-2.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Longo V.D. et al. \u2014 Sirtuins in aging and age-related disease. <em>Biochim Biophys Acta<\/em>, 2006.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<div class=\"year-divider\" id=\"y2003\">2003<\/div>\n<div class=\"pubblicazione-item\">\n    <span class=\"rivista-label\">Science \/ 2003<\/span><br \/>\n    <a class=\"pub-link\" href=\"https:\/\/www.fondazionevalterlongo.org\/wp-content\/uploads\/2026\/04\/2003_Science_EvolutionaryMedicine.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">\u2014 Evolutionary medicine: genetic basis of obesity and diabetes in modern human populations. <em>Science<\/em>, 2003.<span class=\"arrow-icon\">\u2197<\/span><\/a>\n  <\/div>\n<\/div>\n<p class=\"section-note\">Publications are listed in reverse chronological order. Links lead to original articles on PubMed or archived PDFs.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Scientific Publications: Diabetes and Obesity The following collection gathers the main scientific publications on the role of the fasting-mimicking diet, periodic fasting and dietary restriction in the treatment of type 2 diabetes, obesity and related metabolic conditions. 2025 2024 2023 2022 2020 2017 2011 2006 2003 2025 Molecular Metabolism \/ 2025 Sulaj A. et al. &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.fondazionevalterlongo.org\/en\/diabetes-obesity-for-doctors\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;DIABETES &#038; OBESITY&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"patient.php","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-1389","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>DIABETES &amp; 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