{"id":14917,"date":"2024-02-28T11:49:09","date_gmt":"2024-02-28T10:49:09","guid":{"rendered":"https:\/\/www.fondazionevalterlongo.org\/?p=14917"},"modified":"2024-02-28T13:15:54","modified_gmt":"2024-02-28T12:15:54","slug":"fasting-mimicking-diet-the-calorie-restriction-that-can-make-people-biologically-younger","status":"publish","type":"post","link":"https:\/\/www.fondazionevalterlongo.org\/en\/fasting-mimicking-diet-the-calorie-restriction-that-can-make-people-biologically-younger\/","title":{"rendered":"How to Reduce Biological Age and the Risk of Developing Chronic Diseases?"},"content":{"rendered":"
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Art\u00edculo en espa\u00f1ol despu\u00e9s de la versi\u00f3n en ingl\u00e9s<\/h5>\n

 <\/p>\n

The new scientific publication in ‘Nature Communications’ reveals which form of fasting makes these results possible.<\/h2>\n

\u201cThis is the first study to show that a food-based intervention that does not require chronic dietary changes or other lifestyle changes can make people biologically younger.\u201d<\/em> With this statement, Professor Valter Longo summarizes the key message of a new scientific publication in \u201cNature Communications\u201d (https:\/\/pubmed.ncbi.nlm.nih.gov\/38378685\/<\/a>).<\/p>\n

 <\/p>\n

The study is based on the analysis of participants in two different clinical studies, who carried out three 5-day fasting-mimicking diet cycles. Researchers found that following the fasting-mimicking diet resulted in a reduction in biological age and a lower risk of developing age-related diseases such as cancer, diabetes, and heart disease. Participants were therefore healthier and younger, by around 2.5 years.<\/p>\n

 <\/p>\n

What the study consists of<\/strong><\/p>\n

The fasting-mimicking diet, developed at the USC Leonard Davis School of Gerontology in California, USA, is an innovative diet designed to mimic the effects of water-only fasting while still providing all the essential nutrients. The clinically tested protocol consists of a five-day low-calorie diet rich in “healthy” unsaturated fats and low in proteins and simple carbohydrates.<\/p>\n

 <\/p>\n

Fewer illnesses, thanks to fasting and refeeding cycles<\/strong><\/p>\n

The study also highlights how intervention strategies on aging processes should begin early in adulthood to effectively mitigate the cellular and molecular damage that accumulates over time. Alternating fasting-mimicking diet cycles with periods of refeeding in the long term facilitates the elimination of damaged cellular components and allows cellular regeneration, effectively counteracting age-related deterioration.<\/p>\n

The decrease in biological age, when following 3 cycles of fasting-mimicking diet per year, between the ages of 50 and 70 can be up to 11 years younger.<\/strong><\/p>\n

Previous research by Professor Longo has indicated that short periodic cycles of fasting-mimicking diets can promote various metabolic benefits: in particular, optimization of cholesterol, blood pressure, triglycerides, blood sugar, inflammation, and IGF-1 (an insulin-like growth factor, which can be considered a risk factor for oncological diseases) values. Furthermore, it was mainly participants with high initial risk factor values who experienced more pronounced improvements after the fasting-mimicking diet intervention, underlining its potential as a personalized therapeutic approach. The improvement of these parameters allows us to counter metabolic syndrome, a widespread condition linked to the presence of other diseases and cardiovascular mortality.\u00a0The new findings, published in the journal \u201cNature Communications\u201d, revealed that those in the fasting-mimicking diet group had less abdominal and liver fat, a key indicator of metabolic health. Participants also showed a lower risk of diabetes, with, in particular, lower insulin resistance and reduced levels of glycated hemoglobin (crucial markers in diabetes control).<\/p>\n

The new study therefore confirms how the optimization of these parameters lowers the risk of developing the main chronic non-communicable diseases such as diabetes, cancer, cardiovascular diseases, and neurodegenerative diseases, such as Alzheimer’s.<\/strong>\u00a0<\/strong><\/p>\n

Rejuvenation of the immune system <\/strong>Yet another element to consider is an increase in the lymphocyte-myeloid ratio, an indicator of a younger immune system. An increase in the lymphocyte-myeloid ratio indicates that there are more lymphocytes in the immune system, that is white blood cells that play a crucial role in adaptive immunity, compared to myeloid cells, involved in innate immunity. This increase is interpreted as a sign of a younger or more active immune system. Since lymphocytes are associated with specific and targeted immune responses, a greater ratio suggests greater efficiency of the immune system in responding to external challenges.\u00a0The fasting-mimicking diet, as shown in the data published by this innovative scientific research, seems to exert positive effects on the immune profile, with evidence suggesting rejuvenating impacts on the immune system, similar to what has been observed in animal studies.In fact, aging is often accompanied by immunosenescence, characterized by an altered production and function of immune cells, which lead to greater susceptibility to disease.<\/p>\n

The results of the new study appear to be independent of weight loss, which is achieved with calorie restriction. The effect is therefore not secondary to weight loss, but specific to this protocol.<\/strong><\/p>\n

In conclusion, accumulating evidence appears to support the role of the fasting-mimicking diet as a promising intervention to promote health extension and mitigate age-related health decline. Further research and longitudinal studies are needed to clarify the long-term effects and optimize the implementation of the said regimen for personalized health management strategies.\u00a0How to eat between one fasting cycle and another?<\/strong>Everyday nutrition, as a whole, also affects long-term health. Studies on aging and nutrition in simple organisms, rodents, monkeys, and humans have made it possible to link longevity to conserved metabolic and growth pathways to define their role in aging and age-related diseases. A viable and effective nutritional strategy in delaying aging and\/or preventing disease is the \u201cLongevity Diet<\/strong>\u201d. Its characteristics are based on the analysis of scientific studies but also on the habits of healthy centenarians. Personalization of the Longevity Diet, which also includes the fasting-mimicking diet, is crucial in optimizing lifespan and health. \u00a0It is important, for any form of fasting, to be followed by a professional expert in the application of these protocols, given the high risks of a do-it-yourself approach. To evaluate personalized strategies, the nutritionists of the European Longevity Institute at the non-profit Valter Longo Foundation, trained by Professor Valter Longo, are available at the email address nutrizionisti@fondazionevalterlongo.org<\/a>.<\/p>\n

\ud83c\uddea\ud83c\uddf8 \u00bfC\u00f3mo reducir la edad biol\u00f3gica y disminuir el riesgo de desarrollar enfermedades cr\u00f3nicas?<\/h1>\n

La nueva publicaci\u00f3n cient\u00edfica en Nature Communications revela que forma de ayuno hace posible estos resultados.<\/h2>\n

\u201cEste es el primer estudio que demuestra que una intervenci\u00f3n basada en la comida que no requiere cambios diet\u00e9ticos cr\u00f3nicos u otros cambios de estilo de vida puede hacer a las personas m\u00e1s j\u00f3venes biol\u00f3gicamente.\u201d<\/em> Con esta declaraci\u00f3n el Profesor Valter Longo resume el mensaje principal de una nueva publicaci\u00f3n cient\u00edfica en Nature Communications <\/em>(https:\/\/pubmed.ncbi.nlm.nih.gov\/38378685\/<\/a>).<\/p>\n

El estudio se basa en el an\u00e1lisis de participantes en dos distintos estudios cl\u00ednicos, que efectuaron tres ciclos de dieta mima-ayuno (que imita al ayuno) de 5 d\u00edas. Los investigadores descubrieron que las personas que siguieron la dieta mima-ayuno hab\u00edan tenido como resultado una reducci\u00f3n de su edad biol\u00f3gica y menor riesgo de desarrollar una enfermedad ligada al envejecimiento como el c\u00e1ncer, diabetes y enfermedades card\u00edacas.<\/p>\n

Los participantes eran, por lo tanto, m\u00e1s sanos y resultaron m\u00e1s j\u00f3venes, por cerca de 2.5 a\u00f1os.<\/p>\n

En qu\u00e9 consiste el estudio<\/strong><\/p>\n

La dieta mima-ayuno, desarrollada en la Escuela de Gerontolog\u00eda Leonard Davis de USC en California, EUA, es una dieta innovadora dise\u00f1ada para simular los efectos del ayuno de s\u00f3lo agua, mientras proporciona todos los nutrientes esenciales. El protocolo, cl\u00ednicamente probado, consiste en un r\u00e9gimen alimenticio hipocal\u00f3rico de cinco d\u00edas rico en grasas insaturadas \u201csaludables\u201d y bajo contenido de prote\u00ednas y carbohidratos simples.<\/p>\n

Menos enfermedades, gracias a los ciclos de ayuno y realimentaci\u00f3n<\/strong>\u00a0<\/strong><\/p>\n

El estudio resalta, adem\u00e1s, como las estrategias de intervenci\u00f3n sobre los procesos de envejecimiento deber\u00edan iniciar de manera temprana en la edad adulta para mitigar eficazmente los da\u00f1os celulares y moleculares que se acumulan con el pasar del tiempo. Alternar los ciclos de dieta mima-ayuno con periodos de realimentaci\u00f3n a largo plazo facilita la eliminaci\u00f3n de los componentes celulares da\u00f1ados y permite la regeneraci\u00f3n celular, contrarrestando efectivamente el deterioro ligado a la edad.<\/p>\n

La disminuci\u00f3n de la edad biol\u00f3gica, cuando se hacen 3 ciclos de dieta mima-ayuno al a\u00f1o, entre los 50 y 70 a\u00f1os puede hacer que se llegue con 11 a\u00f1os menos. <\/strong><\/p>\n

Investigaciones precedentes a las del Profesor Longo han indicado que breves ciclos peri\u00f3dicos de dieta mima-ayuno pueden promover diversos beneficios sobre el metabolismo. En particular, una mejora en los valores de colesterol, presi\u00f3n arterial, triglic\u00e9ridos, glucemia, inflamaci\u00f3n e IGF-1 (un factor de crecimiento similar a la insulina, que puede ser considerado como un factor de riesgo para enfermedades oncol\u00f3gicas). Adem\u00e1s, sobre todo los participantes con valores iniciales de factores de riesgo elevados son quienes experimentan un mejoramiento m\u00e1s pronunciado despu\u00e9s de la implementaci\u00f3n de la dieta mima-ayuno, resaltando su potencial como enfoque terap\u00e9utico personalizado.<\/p>\n

El mejoramiento de estos par\u00e1metros permite contrarrestar el s\u00edndrome metab\u00f3lico, una condici\u00f3n ampliamente distribuida ligada a la presencia de otras enfermedades y con la mortalidad cardiovascular.<\/p>\n

Los nuevos resultados, publicados en la revista Nature Communications<\/em>, revelaron que aquellos que formaron parte del grupo dieta mima-ayuno tuvieron menor grasa abdominal y hep\u00e1tica, un indicador clave de la salud metab\u00f3lica. Los participantes mostraron tambi\u00e9n un menor riesgo de diabetes, con una particular resistencia menor a la insulina y niveles reducidos de hemoglobina glucos\u00eddica (marcadores cruciales en el control de la diabetes).<\/p>\n

El nuevo estudio confirma por lo tanto como la mejora de estos par\u00e1metros disminuye el riesgo de desarrollar las principales enfermedades cr\u00f3nicas no transmisibles como diabetes, c\u00e1ncer, enfermedades cardiovasculares y enfermedades neurodegenerativas, como el Alzheimer. <\/strong>\u00a0<\/strong><\/p>\n

Rejuvenecimiento del sistema inmunitario <\/strong><\/p>\n

A todo esto, se le a\u00f1ade un aumento de la proporci\u00f3n linfocitos-mieloides, indicador de un sistema inmunitario m\u00e1s joven. Un aumento de la proporci\u00f3n linfocitos-mieloides indica, de hecho, que en el sistema inmunitario hay m\u00e1s linfocitos, gl\u00f3bulos blancos que llevan a cabo una funci\u00f3n crucial en la inmunidad adaptativa, respecto a c\u00e9lulas mieloides, involucradas en la inmunidad innata. Este incremento se interpreta como signo de un sistema inmunitario m\u00e1s joven y activo. Debido a que los linfocitos est\u00e1n asociados a la respuesta inmune espec\u00edfica y dirigida, una mayor cantidad de estas c\u00e9lulas sugiere una mayor eficiencia del sistema inmune para responder a los desaf\u00edos externos.<\/p>\n

La dieta mima-ayuno, con base a la lectura de los resultados publicados de tal investigaci\u00f3n cient\u00edfica innovadora, parece ejercer efectos positivos sobre el perfil inmunitario, con pruebas que sugieren impactos rejuvenecedores sobre el sistema inmunitario, similares a los observados en estudios en animales.<\/p>\n

A menudo, de hecho, el envejecimiento es acompa\u00f1ado de la inmunosenescencia, caracterizada por la producci\u00f3n y funci\u00f3n alterada de las c\u00e9lulas inmunitarias, que llevan a una mayor susceptibilidad a enfermedades.<\/p>\n

Los resultados del nuevo estudio parecen ser independiente de la p\u00e9rdida de peso, que se obtiene como resultado de la restricci\u00f3n cal\u00f3rica. El efecto no es por lo tanto secundario de la p\u00e9rdida de peso, pero espec\u00edfico de este protocolo. <\/strong><\/p>\n

En conclusi\u00f3n, las pruebas acumuladas parecen apoyar el papel de la dieta mima-ayuno como intervenci\u00f3n prometedora para promover la extensi\u00f3n de la salud y mitigar el declive de la salud ligado a la edad. Investigaciones adicionales y estudios longitudinales son necesarios para aclarar los efectos a largo plazo y optimizar la implementaci\u00f3n de dicho r\u00e9gimen para estrategias personalizadas de gesti\u00f3n de la salud.<\/p>\n

\u00bfC\u00f3mo comer entre uno y otro ciclo de ayuno? <\/strong><\/p>\n

Incluso la alimentaci\u00f3n de todos los d\u00edas, como un todo, influye en la salud a largo plazo.<\/p>\n

Estudios sobre el envejecimiento y la nutrici\u00f3n en organismos simples, roedores, simios y seres humanos han permitido conectar la longevidad con v\u00edas metab\u00f3licas y de crecimiento conservadas para determinar su papel en el envejecimiento y en las enfermedades relacionadas con la edad. Una estrategia nutricional pr\u00e1ctica y eficaz en el retardo del envejecimiento y\/o prevenci\u00f3n de las enfermedades es la \u201cDieta de la Longevidad\u201d. <\/strong>Las caracter\u00edsticas de la cual se basan en el an\u00e1lisis de estudios cient\u00edficos, as\u00ed como tambi\u00e9n en los h\u00e1bitos de los \u201ccentenarios\u201d sanos.<\/p>\n

La personalizaci\u00f3n de la dieta de la longevidad, que comprende tambi\u00e9n la dieta mima-ayuno, es crucial en la mejora de la duraci\u00f3n de la vida y la salud. Es importante, cual sea la forma de ayuno, ser orientado por un profesional experto en la aplicaci\u00f3n de tales protocolos, dado los altos riesgos de hacerlo por uno mismo. Para evaluar las estrategias personalizadas, los nutricionistas del Instituto Europeo de la Longevidad de la Fundaci\u00f3n Valter Longo Onlus, formados por el Profesor Valter Longo, est\u00e1n a disponibilidad en el siguiente correo electr\u00f3nico:\u00a0 nutrizionisti@fondazionevalterlongo.org<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Art\u00edculo en espa\u00f1ol despu\u00e9s de la versi\u00f3n en ingl\u00e9s   The new scientific publication in ‘Nature Communications’ reveals which form of fasting makes these results possible. \u201cThis is the first study to show that a food-based intervention that does not require chronic dietary changes or other lifestyle changes can make people biologically younger.\u201d With this … <\/p>\n

Continue reading “How to Reduce Biological Age and the Risk of Developing Chronic Diseases?”<\/span><\/a><\/p>\n","protected":false},"author":30,"featured_media":15306,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"inline_featured_image":false,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-14917","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nHow to Reduce Biological Age and the Risk of Developing Chronic Diseases? - Fondazione Valter Longo<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fondazionevalterlongo.org\/en\/fasting-mimicking-diet-the-calorie-restriction-that-can-make-people-biologically-younger\/\" \/>\n<meta property=\"og:locale\" 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