Scientific Publications: Diabetes and Obesity

The following collection gathers the main scientific publications on the role of the fasting-mimicking diet, periodic fasting and dietary restriction in the treatment of type 2 diabetes, obesity and related metabolic conditions.

2025

Molecular Metabolism / 2025
Sulaj A. et al. — Effects of periodic fasting on glucose metabolism and diabetic nephropathy: long-term follow-up. Mol Metab, 2025.↗

Journal of Personalized Medicine / 2025
Roshan S. et al. — Personalized approaches to the fasting-mimicking diet in the treatment of type 2 diabetes: clinical evidence. J Pers Med, 2025.↗

Metabolic Health and Disease / 2025
Mishra A. et al. — IGF-I deficiency and metabolic protection in diabetes: mechanisms and clinical implications. Metab Health Dis, 2025.↗

Cell Reports Medicine / 2025
Micarelli A. et al. — Effects of the fasting-mimicking diet on biological age markers and metabolic risk. Cell Rep Med, 2025.↗

2024

Diabetologia / 2024
van den Burg E.L. et al. — Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial. Diabetologia, 2024.↗

Nature Communications / 2024
Brandhorst S. et al. — Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nat Commun, 15(1):1309, 2024.↗

Med / 2024
Mishra A. et al. — Normal or improved metabolic risk factors in IGF-I-deficient adults with growth hormone receptor deficiency. Med, 2024.↗

Value in Health / 2024
Habka D. et al. — Cost-effectiveness analysis of the fasting-mimicking diet in the treatment of type 2 diabetes in primary care. Value Health, 2024.↗

2023

Metabolic Health and Disease / 2023
Mishra A. et al. — IGF-I deficiency and reduced metabolic risk: evidence from populations with growth hormone receptor deficiency. Metab Health Dis, 2023.↗

2022

The Journal of Clinical Endocrinology and Metabolism / 2022
Sulaj A. et al. — Six-month periodic fasting in patients with type 2 diabetes and diabetic nephropathy: a proof-of-concept study. J Clin Endocrinol Metab, 107(8):2167-2181, 2022.↗

2020

BMC Endocrine Disorders / 2020
van den Burg E.L. et al. — Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes. BMC Endocr Disord, 20(1):164, 2020.↗

2017

Cell / 2017
Cheng C.W. et al. — Fasting-mimicking diet promotes Ngn3-driven β-cell regeneration to reverse diabetes. Cell, 2017.↗

Science Translational Medicine / 2017
Wei M. et al. — Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med, 9(377):eaai8700, 2017.↗

2011

Science Translational Medicine / 2011
Guevara-Aguirre J. et al. — Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med, 2011.↗

2006

Biochimica et Biophysica Acta / 2006
Longo V.D. et al. — Sirtuins in aging and age-related disease. Biochim Biophys Acta, 2006.↗

2003

Science / 2003
— Evolutionary medicine: genetic basis of obesity and diabetes in modern human populations. Science, 2003.↗

Publications are listed in reverse chronological order. Links lead to original articles on PubMed or archived PDFs.

For Physicians

Scientific Publications: Diabetes and Obesity

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