Scientific Publications: Neurodegenerative Diseases

The following collection gathers the main scientific publications on the role of fasting, fasting-mimicking diet and protein restriction in neurodegenerative diseases, with particular focus on Alzheimer’s disease, multiple sclerosis and mechanisms of neuronal aging.

2022

Cell Reports / 2022
Rangan P. et al. — Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer’s models. Cell Rep, 40(13):111417, 2022.↗

2017

The Journal of Neuroscience / 2017
Nashiro K. et al. — Brain structure and function associated with younger adults in growth hormone receptor-deficient humans. J Neurosci, 2017.↗

2016

Cell Reports / 2016
Choi I.Y. et al. — A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms. Cell Rep, 2016.↗

2013

Aging Cell / 2013
Parrella E. et al. — Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer’s disease mouse model. Aging Cell, 2013.↗

2010

The Scientific World Journal / 2010
Parrella E. et al. — Insulin/IGF-I and related signaling pathways regulate aging in non-dividing cells: from yeast to the mammalian brain. ScientificWorldJournal, 2010.↗

2009

Neuroendocrinology / 2009
Wong A.M. et al. — Progesterone influence on neurite outgrowth involves microglia. Endocrinology, 2009.↗

2008

Cell Metabolism / 2008
— SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab, 2008.↗

2006

Biochimica et Biophysica Acta / 2006
Longo V.D. et al. — Sirtuins in aging and age-related disease. Biochim Biophys Acta, 2006.↗

2005

Neuroscience Letters / 2005
— Effects of aging on neurons and glial cells in the central nervous system. Neurosci Lett, 2005.↗

2004

Neuroscience Letters / 2004
— Progressive changes in regulation of apolipoproteins E and J in glial cultures during postnatal development and aging. Neurosci Lett, 2004.↗

Neurobiology of Aging / 2004
— Reversible age impairments in neurite outgrowth by manipulations of astrocytic GFAP. Neurobiol Aging, 2004.↗

2002

The Journal of Neuroscience / 2002
— Peroxynitrite mediates neurotoxicity of amyloid β-peptide 1–42 and lipopolysaccharide-activated microglia. J Neurosci, 2002.↗

Endocrinology / 2002
— Estradiol (E2) enhances neurite outgrowth by repressing glial fibrillary acidic protein expression and reorganizing laminin. Endocrinology, 2002.↗

Archives of Neurology / 2002
— Genetics of aging and diseases. Arch Neurol, 2002.↗

2000

Journal of Neurochemistry / 2000
— Reversible inactivation of superoxide-sensitive aconitase in Aβ1–42-treated neuronal cell lines. J Neurochem, 2000.↗

1999

Experimental Neurology / 1999
— Variations of synaptotagmin I, synaptotagmin IV, and synaptophysin mRNA levels in rat hippocampus during the estrous cycle. Exp Neurol, 1999.↗

Neurobiology of Aging / 1999
— Aging and regulation of neuronal growth: implications for neurodegenerative diseases. Neurobiol Aging, 1999.↗

Publications are listed in reverse chronological order. Links lead to original articles on PubMed or archived PDFs.